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Asthma and COPD "overlap": a treatable trait or common several treatable-traits?

J Gaspar Marques1,2, M Lobato1, P Leiria Pinto1,2

  • 1Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, E.P.E., Lisboa, Portugal.

European Annals of Allergy and Clinical Immunology
|March 20, 2020
PubMed

Insights

The treatable traits approach offers a framework for managing chronic respiratory diseases (CRD), including asthma-COPD overlap. This review details pulmonary, extra-pulmonary, and lifestyle factors for improved patient outcomes.

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Practice

Background:

  • Recent discussions have focused on classifying chronic respiratory diseases (CRD), introducing concepts like asthma-COPD overlap (ACO).
  • The GOLD consensus (2020) controversially suggested discontinuing the ACO term, viewing asthma and COPD as distinct entities with shared features.
  • The treatable traits approach provides a structured method for managing complex respiratory conditions.

Purpose of the Study:

  • To review the application of the treatable traits approach in chronic respiratory diseases (CRD).
  • To detail identified treatable traits in patients with asthma and COPD.
  • To highlight the clinical relevance of treatable traits for managing CRD.

Main Methods:

  • Literature review focusing on the treatable traits approach in CRD.
  • Identification and categorization of treatable traits in asthma and COPD patients.
  • Analysis of the strengths and applicability of the treatable traits framework.

Main Results:

  • Treatable traits in CRD encompass pulmonary, extra-pulmonary, and behavioral/lifestyle factors.
  • Patients with asthma and COPD exhibit identifiable treatable traits across all categories.
  • Key issues include frequent exacerbations, comorbid cardiovascular disease, and reduced quality of life.

Conclusions:

  • The treatable traits approach is highly applicable to managing CRD, including patients with overlapping asthma and COPD features.
  • Addressing identified treatable traits can potentially mitigate severe exacerbations and improve patient outcomes.
  • Further application of this approach may enhance health-related quality of life and productivity in CRD patients.
Abstract

Keywords:
AsthmaAsthma-Chronic Obstructive Pulmonary Disease Overlap SyndromeChronic Obstructivecomorbiditydiagnosisdifferentialpulmonary disease

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