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Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
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Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's

Dallas Bednarczyk1, Menaka V Sanghvi1

  • 1Pharmacokinetic Sciences, Novartis Institutes of BioMedical Science, Cambridge, MA, USA.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|March 20, 2020
PubMed
Summary

This study identified novel organic anion transporting polypeptide (OATP) 2B1 substrates, including angiotensin II receptor blockers (ARBs). However, OATP2B1 has minimal impact on oral absorption and brain penetration of these substrates.

Keywords:
OATP2B1Organic anion transporting polypeptideangiotensin II receptor blockerbrain penetrationcoproporphyrindrug absorption

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