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MFO activity changes in single living 3T3 fibroblasts treated with adriamycin
S Lahmy1, J M Salmon, P Viallet
1Laboratorie de Chimie Physique, Université de Perpignan, France.
Anticancer Research
|November 1, 1988
Abstract:
The effects of Adriamycin on 3T3 fibroblasts has been followed by microspectrofluorimetry. MFO activity was monitored by BaP metabolism and three points were studied: long-term ADR treatment, reversibility of this treatment and cysteamine effect on ADR treatment. The appearance of a sub-population that does not accumulate BaP suggests either a greater efflux of BaP or no penetration of the compound after ADR treatment. Moreover drastic morphological changes were observed.