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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Fine needle cytology features of an atypical presentation of infectious mononucleosis

Roberto Gerber-Mora1, Verónica Peña Y Lillo2, Ricardo Moreno-Silva2

  • 1Medicina Bucal y Maxilofacial, Latin University of Costa Rica, San José, Costa Rica.

Journal of Oral and Maxillofacial Pathology : JOMFP
|March 20, 2020
PubMed

Insights

This case report details a 21-year-old female experiencing infectious mononucleosis (IM) reactivation. She presented solely with asymptomatic lymph node enlargement, highlighting atypical IM presentations.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • Infectious mononucleosis (IM), often caused by Epstein-Barr virus (EBV), is typically characterized by pharyngitis, lymphadenopathy, and pyrexia.
  • Diagnosis can be challenging due to atypical presentations, including gastrointestinal or dermatological symptoms.
  • Reactivation of IM, while less common, can occur and may present with varied clinical manifestations.

Observation:

  • A 21-year-old female presented with a reactivation of infectious mononucleosis.
  • The patient exhibited multiple, asymptomatic lymph node enlargements exclusively in the head and neck region.
  • No other typical or atypical symptoms of IM, such as fever, pharyngitis, or malaise, were present.

Findings:

  • The case demonstrates a rare presentation of IM reactivation.
  • Asymptomatic lymphadenopathy in the head and neck can be the sole manifestation of IM.
  • This presentation underscores the importance of considering IM even in the absence of classic symptoms.

Implications:

  • Clinicians should consider atypical presentations of IM, including isolated lymphadenopathy.
  • Diagnostic workup for unexplained lymphadenopathy should include evaluation for IM, especially in young adults.
  • This case expands the spectrum of clinical manifestations for infectious mononucleosis reactivation.
Keywords:
Epstein Barrhead and neckreactivationsmear

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