[Partial purification and various characteristics of antibacterial factor in preparations of interferon]

A factor showing antibacterial activity was isolated from human alpha-interferon native preparations with affinity chromatography on immobilized cells of staphylococci. The antibacterial activity was found to be stable to the effect of nucleases and heating. Exposure to trypsin activated the antibacterial activity while exposure to pepsin somewhat destroyed it. Growth of the staphylococcal culture resistant to antibiotics was inhibited by the factor.