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Clinically Meaningful Difference for the Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R): A

Adam B Smith1, Neil Fawkes2, Helen Kotze3

  • 1Health Outcomes, Medical Affairs & Evidence Generation, Reckitt Benckiser, Hull, UK.

Patient Related Outcome Measures
|March 20, 2020
PubMed

Insights

This study determined a clinically important difference (CID) for the Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R). A threshold of approximately 6 indicates a significant change in infant gastroesophageal reflux disease symptoms.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Clinical Outcomes Research

Background:

  • Gastroesophageal reflux disease (GORD) is prevalent in 30% of infants.
  • The Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R) assesses GORD impact in infants.
  • Limited data exists on the clinically important difference (CID) for the I-GERQ-R.

Purpose of the Study:

  • To determine the clinically important difference (CID) for the I-GERQ-R in infants.
  • To establish a threshold for meaningful change in GORD symptom severity.

Main Methods:

  • A systematic literature review of longitudinal studies using the I-GERQ-R was conducted.
  • Data from 7 selected articles, including 661 infants, were analyzed.
  • A random effects model was employed to calculate the overall CID.

Main Results:

  • The overall CID for the I-GERQ-R was calculated as -6.54.
  • A threshold of approximately 6 suggests a clinically important difference.
  • A minimally important difference may be indicated by a threshold of 3 to 4.

Conclusions:

  • A CID for the I-GERQ-R was successfully derived.
  • The findings provide guidance for interpreting I-GERQ-R scores in clinical practice.
  • This research aids in evaluating meaningful symptom changes in infants with GORD.
Abstract

Keywords:
I-GERQ-Rclinically important differencegastro-esophageal reflux diseaseminimally important difference

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