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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Runners' metabolomic changes following marathon.

Rengfei Shi1, Jin Zhang1, Biqing Fang1

  • 11School of Kinesiology, Shanghai University of Sport, 188 Hengren Road, Yangpu District, Shanghai, 200438 China.

Nutrition & Metabolism
|March 20, 2020
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Summary

Marathon running significantly alters athletes' serum metabolome, enhancing glucose and lipid metabolism while decreasing glucosamine and increasing caffeine metabolism. These findings offer insights into marathon performance and nutritional status.

Keywords:
ExerciseMarathonMetabolomicsSerum

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Area of Science:

  • Human metabolomics
  • Exercise physiology
  • Biochemistry

Background:

  • Marathon running is a popular aerobic exercise with limited understanding of its holistic impact on the serum metabolome.
  • Investigating metabolic changes post-marathon is crucial for athlete performance and health.

Purpose of the Study:

  • To comprehensively analyze the effects of marathon running on human serum metabolomics.
  • To explore the interrelationships among various metabolites before and after a marathon.

Main Methods:

  • Serum samples from 20 male marathon runners were collected pre- and post-race.
  • Untargeted two-dimensional gas chromatography time-of-flight mass spectrometry was used for metabolite identification.

Main Results:

  • Significant increases in serum urea, creatine kinase, cortisol, and various metabolites including pyruvic acid, glyceric acid, and lipid indicators were observed.
  • Significant decreases in serum testosterone, glucosamine, and certain amino acids like serine and valine were noted.
  • Correlations were found between marathon performance, body composition, VO2max, hemoglobin, and serum testosterone/cortisol levels.

Conclusions:

  • Marathon completion enhances glucose and lipid metabolism in athletes.
  • Glucosamine metabolism decreases, while caffeine metabolism increases post-marathon.
  • The study provides novel insights into marathon performance and the nutritional status of athletes.