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An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging
Yan Xu1, Weitao Yang1, Defan Yao2
1Department of Medical Ultrasound , Shanghai Tenth People's Hospital , Tongji University Cancer Center , Tongji University School of Medicine , Shanghai 200072 , China .
Chemical Science
|March 20, 2020
Summary
We developed a new semiconducting polymer afterglow luminogen using aggregation-induced emission dyes. This enhances afterglow intensity and duration for improved in vivo tumor imaging with high signal-to-noise ratios.
Area of Science:
- Materials Science
- Biomedical Imaging
- Organic Electronics
Background:
- Semiconducting polymers (SPs) show promise for in vivo imaging due to long-lived luminescence.
- Current SP afterglow agents suffer from low intensity and short duration, limiting their application.
- Aggregation-induced emission (AIE) dyes can overcome concentration quenching and enhance luminescence.
Purpose of the Study:
- To develop a novel SP afterglow luminogen with enhanced performance.
- To leverage AIE dye characteristics to improve afterglow intensity and duration.
- To investigate the mechanism behind the enhanced afterglow luminescence.
Main Methods:
- Synthesized an AIE dye-powered SP afterglow luminogen.
- Investigated the working mechanism using experimental studies.
- Evaluated the luminogen's performance in in vivo tumor imaging.
Main Results:
- The AIE dye enhanced afterglow intensity and prolonged duration by circumventing concentration quenching.
- A closed-loop mechanism involving photons, singlet oxygen (¹O₂), and SP intermediates was identified.
- The developed luminogen demonstrated effective in vivo tumor imaging with deep-red emission.
Conclusions:
- AIE-facilitated SP afterglow luminogens offer significant advantages for biomedical imaging.
- The developed material shows potential for improved cancer theranostics.
- This work provides insights into the mechanism of AIE-enhanced afterglow luminescence.
