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Evaluation of the Relationship Between Clinical Symptoms and Modic Changes
1Neurosurgery, Memorial Şişli Hospital, İstanbul, TUR.
Cureus
|March 20, 2020
Summary
Modic changes (MCs) in the spine can change type or resolve over time. Type 1 Modic changes are significantly associated with increased low back pain, highlighting their clinical relevance.
Area of Science:
- Radiology
- Orthopedics
- Pain Management
Background:
- Modic changes (MCs) are common findings on spinal magnetic resonance imaging (MRI).
- The dynamic nature and clinical significance of Modic changes, particularly their evolution and association with low back pain, require further investigation.
Purpose of the Study:
- To evaluate the association between changes in Modic change (MC) type, the development of new MCs, and low back symptoms.
- To investigate the temporal relationship and clinical correlation of Modic changes over time.
Main Methods:
- Retrospective study of patients with low back pain and at least two MRI scans between 2013 and 2016.
- Inclusion criteria: patients with Modic changes (MCs) on MRI; exclusion: MRI intervals less than six months.
- Evaluation of 774 vertebrae across 129 patients to assess changes in MC presence and type.
Main Results:
- Modic changes (MCs) were present in 37% of vertebrae initially, increasing to 43% at the second MRI.
- New MCs developed in 59 vertebrae, and complete resolution occurred in two patients.
- Type 1 MCs showed a significant positive association with pain (p=0.001) compared to other types.
Conclusions:
- Modic changes (MCs) demonstrate variability over time, including transformation between types and complete resolution.
- Type 1 Modic changes are significantly correlated with increased low back pain severity, as measured by the visual analog scale (VAS).
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