Disseminated cryptococcosis in an immunocompetent patient
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Updated: Dec 26, 2025

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Published on: March 1, 2024
Rahul Bollam1, Mohamed Yassin1, Tung Phan2
1Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Abstract:
Cryptococcosis is an important opportunistic infection. It is the third most common invasive fungal infection in solid organ transplant recipients. The primary organ affected is the lungs, but infection of the central nervous system and other organ systems are also seen. Here we reported a case of disseminated cryptococcosis in a healthy patient who presented with severe pneumonia, a left upper lobe nodule and enlarged mediastinal lymphadenopathy on a chest computed tomography scan.
Insights
Cryptococcosis is a serious fungal infection, often opportunistic. This case highlights disseminated cryptococcosis in a previously healthy individual presenting with severe pneumonia and related findings.
Area of Science:
- Mycology
- Infectious Diseases
- Immunocompromised Hosts
Background:
- Cryptococcosis is a significant opportunistic fungal infection.
- It ranks as the third most common invasive fungal infection in solid organ transplant recipients.
- While primarily affecting the lungs, it can spread to the central nervous system and other organs.
Observation:
- A case of disseminated cryptococcosis was observed.
- The patient was previously healthy.
- The patient presented with severe pneumonia, a left upper lobe nodule, and enlarged mediastinal lymphadenopathy.
Findings:
- Disseminated cryptococcosis was confirmed in a healthy individual.
- Chest computed tomography revealed severe pneumonia, a nodule, and lymphadenopathy.
- This presentation underscores cryptococcosis's potential beyond immunocompromised states.
Implications:
- This case expands the understanding of cryptococcosis presentation.
- It suggests that healthy individuals can develop severe disseminated forms of the infection.
- Further research into risk factors and early detection in diverse populations is warranted.
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