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Involvement of lncRNAs and Macrophages: Potential Regulatory Link to Angiogenesis
1Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Abstract:
Macrophages are involved in angiogenesis, an essential process for organ growth and tissue repair, and could contribute to the pathogenesis of angiogenesis-related diseases such as malignant tumors and diabetic retinopathy. Recently, long noncoding RNAs (lncRNAs) have been proved to be important in cell differentiation, organismal development, and various diseases of pathological angiogenesis. Moreover, it has been indicated that numerous lncRNAs exhibit different functions in macrophage infiltration and polarization and regulate the secretion of inflammatory cytokines released by macrophages. Therefore, the focus of macrophage-related lncRNAs could be considered to be a potential method in therapeutic targeting angiogenesis-related diseases. This review mainly summarizes the roles played by lncRNAs which associated with macrophages in angiogenesis. The possible mechanisms of the regulatory link between lncRNAs and macrophages in various angiogenesis-related diseases were also discussed.
Insights
Long noncoding RNAs (lncRNAs) regulate macrophages in angiogenesis, offering potential therapeutic targets for diseases like cancer and diabetic retinopathy. This review explores lncRNA roles in macrophage-mediated pathological angiogenesis.
Area of Science:
- Molecular Biology
- Immunology
- Pathology
Background:
- Macrophages play a crucial role in angiogenesis, vital for tissue repair and organ development.
- Dysfunctional angiogenesis contributes to diseases like malignant tumors and diabetic retinopathy.
- Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cellular processes and disease pathogenesis.
Purpose of the Study:
- To review the involvement of lncRNAs associated with macrophages in angiogenesis.
- To discuss the mechanisms by which lncRNAs regulate macrophage functions in angiogenesis.
- To explore the therapeutic potential of targeting lncRNA-macrophage interactions in angiogenesis-related diseases.
Main Methods:
- Literature review of studies on lncRNAs, macrophages, and angiogenesis.
- Analysis of mechanisms underlying lncRNA regulation of macrophage infiltration and polarization.
- Discussion of lncRNA involvement in pathological angiogenesis in various diseases.
Main Results:
- lncRNAs modulate macrophage infiltration and polarization, impacting angiogenesis.
- lncRNAs influence the secretion of inflammatory cytokines by macrophages.
- Specific lncRNAs are implicated in the pathogenesis of angiogenesis-related diseases.
Conclusions:
- lncRNA-macrophage interactions are critical in regulating angiogenesis.
- Targeting these interactions presents a promising therapeutic strategy for angiogenesis-related diseases.
- Further research into lncRNA mechanisms can advance treatments for conditions like cancer and diabetic retinopathy.
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