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[Immune system disorders in acute pyelonephritis. II art]
M N Shatokhin1,2,3, A I Konoply1,2,3, I M Kholimenko1,2,3
1Russian Medical Academy of Continuous Further Professional Education of the Ministry of Healthcare of the Russian Federation, Urological Center of the Scientific Clinical Center of Russian Railways, Moscow, Russia.
Urologiia (Moscow, Russia : 1999)
|March 20, 2020
Summary
This review details immune system changes in acute pyelonephritis, finding obstructive and purulent forms cause more significant immune disorders. Understanding these immune responses aids in optimizing treatment for kidney infection.
Area of Science:
- Nephrology
- Immunology
- Infectious Diseases
Background:
- Acute pyelonephritis involves local and systemic immune responses.
- Understanding immune status changes is crucial for effective treatment.
- Existing literature highlights immune dysregulation in various pyelonephritis forms.
Purpose of the Study:
- To review and analyze immune status changes in different forms of acute pyelonephritis.
- To detail immunological parameters in non-obstructive, obstructive, serous, and purulent pyelonephritis.
- To provide recommendations for monitoring and optimizing treatment based on immune status.
Main Methods:
- Comprehensive literature review of national and international studies.
- Analysis of immunological parameters at local and systemic levels.
- Comparative assessment of immune changes across pyelonephritis subtypes.
Main Results:
- Obstructive and purulent pyelonephritis exhibit more pronounced changes in cytokines and complement factors.
- Serous and non-obstructive forms show comparatively milder immune alterations.
- Specific patterns of immune dysregulation are identified for each pyelonephritis type.
Conclusions:
- Immune status monitoring is recommended for tailoring acute pyelonephritis treatment.
- Distinct immune profiles correlate with pyelonephritis severity and form.
- Pathogenetic and immunotherapy strategies can be informed by these findings.
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