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Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones

Bo Hu1,2, Xiao Lv1,3, Hao Chen1

  • 1Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, USA.

The Journal of Clinical Investigation
|March 20, 2020
PubMed
Summary

Sensory nerves regulate bone mass by releasing prostaglandin E2 (PGE2), which activates EP4 receptors. This pathway inhibits fat cell formation and promotes bone growth in adult mice.

Keywords:
Adult stem cellsBone BiologyBone marrow differentiationStem cells

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