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A Molecular Collapse and the Mental "Falling Down"
1Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest 1083, Hungary.
Abstract:
By exploiting an arsenal of state-of-the-art imaging and genetic manipulation approaches, in this issue of Neuron, Marcus et al. (2020) reveal that the synapse-specific breakdown of endocannabinoid signaling in the prelimbic prefrontal cortex is a core neurobiological substrate for stress-induced, anxiety-like behaviors.
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