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Friction-Limited Folding of Disulfide-Reduced Monomeric SOD1

Noah R Cohen1, Can Kayatekin2, Jill A Zitzewitz1

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.

Biophysical Journal
|March 20, 2020
PubMed
Summary

The folding of monomeric superoxide dismutase (mSOD1) is friction-limited, particularly in its disulfide-reduced state. This internal chain friction may contribute to the aggregation of SOD1 linked to amyotrophic lateral sclerosis.

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