Carbohydrate-deficient transferrin (CDT) in serum in women with early alcohol addiction

Carbohydrate-deficient transferrin (CDT) in serum was determined by micro anion exchange chromatography and a transferrin radioimmune assay in 58 consecutive women treated for early alcohol dependence compared, with 62 healthy females with an alcohol consumption of 0-15 g of ethanol/day. The upper normal CDT level was 74 mg/l. CDT was elevated above this value in 83% of the alcoholic women with an intake of 60 g of ethanol/day or more for at least 7 days within the preceding two weeks. CDT values were significantly positively correlated with daily alcohol consumption but not with GT, ASAT, ALAT or MCV. During abstinence CDT level declined exponentially with a half-life of 14 +/- 3 days. The results indicated that CDT may be as sensitive and specific a marker in women with early alcohol addiction as in previously studied male alcoholics. The amount of alcohol consumed appeared to be more important than sex or liver function. Determination of CDT may thus offer a means for early objective diagnosis and adequate treatment also of women in early stages of alcoholism.