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A consensus-based framework for conducting and reporting osteoarthritis phenotype research.

W E van Spil1, S M A Bierma-Zeinstra2,3, L A Deveza4

  • 1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands. w.e.vanspil@umcutrecht.nl.

Arthritis Research & Therapy
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) heterogeneity research needs standardized definitions for distinct OA subtypes. This study provides consensus definitions and reporting recommendations to advance OA phenotype classification and patient management.

Keywords:
Consensus (maximum 10)FrameworkOsteoarthritisPhenotypes

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Biomedical Research

Background:

  • Osteoarthritis (OA) heterogeneity is increasingly recognized, suggesting distinct subtypes require tailored research and clinical approaches.
  • Operationalizing OA heterogeneity presents challenges due to diverse expert opinions.
  • A consensus framework for OA phenotype research is needed.

Purpose of the Study:

  • To establish consensus-based definitions for OA phenotypes.
  • To develop recommendations for reporting OA phenotype research.
  • To create a framework for advancing OA phenotype classification and management.

Main Methods:

  • A 25-member expert panel conducted an online Delphi exercise.
  • Panelists provided input on definitions and reporting recommendations for OA phenotype studies.
  • Four rounds of Delphi consensus were achieved.

Main Results:

  • Eleven consensus definitions and statements regarding OA phenotypes were agreed upon.
  • OA phenotypes are defined as OA subtypes with distinct pathobiological and pain mechanisms, structural, and functional consequences.
  • Recommendations for reporting OA phenotype studies were established, covering study characteristics, populations, data collection, analysis, and appraisal.

Conclusions:

  • Consensus definitions and reporting recommendations for OA phenotypes have been established.
  • The developed framework aims to facilitate OA phenotype research and classification.
  • This work is expected to lead to more effective, individualized OA management strategies for patients.