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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

168
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
168
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

190
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
190
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

146
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
146
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

142
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
142
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

141
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
141
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

169
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
169

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Verifying Medication Orders in the Older Population: Are We Using Enough Caution?

Ali Scrimenti, Luke A Probst, Christopher D Miller

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    This summary is machine-generated.

    Pharmacists use more caution and resources for pediatric medication orders than geriatric ones. This study highlights a need for consistent safety practices across all patient age groups to ensure comprehensive care.

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    Area of Science:

    • Pharmacy Practice
    • Medication Safety
    • Health Services Research

    Background:

    • Hospital pharmacists' practices in processing pediatric versus geriatric medication orders are not well-characterized.
    • Existing hypotheses suggest differential resource utilization and caution levels based on patient age group.

    Purpose of the Study:

    • To investigate whether hospital pharmacists apply greater caution and utilize more drug information resources for pediatric medication orders compared to geriatric medication orders.
    • To assess the perceived importance of medication error prevention guidelines for different age groups.

    Main Methods:

    • A 26-item electronic survey was distributed to staff pharmacists at academic medical centers.
    • The survey was administered via academic medical center pharmacy directors and re-sent twice at two-week intervals.
    • Key outcome measures included caution levels, frequency of drug information resource use, and importance of error prevention guidelines.

    Main Results:

    • A majority of pharmacists (72.7%) reported exercising more caution with pediatric medication orders than geriatric ones.
    • Pharmacists were 4.2 times more likely to consult drug information resources for pediatric orders (69.0%) than for geriatric orders (34.3%).
    • Pharmacists familiar with medication error prevention guidelines found pediatric guidelines more important (29.8%) than geriatric guidelines (15.7%).

    Conclusions:

    • Evidence suggests attitudinal differences in pharmacists' work practices when handling pediatric versus geriatric medication orders.
    • The findings indicate a need for consistent application of caution, drug information resource utilization, and adherence to guidelines for both pediatric and geriatric patient populations.
    • Implementing uniform safety standards is crucial for providing safe and comprehensive care to all age groups.