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Rationale and Preclinical Data Supporting Bariatric Arterial Embolization.

Yingli Fu¹, Dara L Kraitchman¹

¹Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD.

Techniques in Vascular and Interventional Radiology

|March 21, 2020

Summary

Bariatric arterial embolization (BAE) offers a minimally invasive treatment for obesity. This image-guided procedure is being studied in early trials as a potential alternative to surgery for weight modulation.

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Area of Science:

Interventional Radiology
Obesity Medicine
Vascular Interventions

Background:

Global obesity rates are rising, increasing disease, death, and healthcare expenses.
Current obesity treatments lack effective, less invasive options compared to bariatric surgery.

Purpose of the Study:

To present the physiological and anatomical basis for Bariatric Arterial Embolization (BAE).
To review BAE techniques for weight modulation.
To summarize preclinical data supporting BAE's clinical application.

Main Methods:

BAE is an image-guided, minimally invasive, percutaneous procedure.
The technique involves embolizing arteries supplying the stomach to reduce hunger hormones.
Preclinical animal models and early clinical trials are used for investigation.

Keywords:

Bariatric embolization Embolics Ghrelin Obesity Weight loss

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Main Results:

Preclinical studies demonstrate the feasibility and potential efficacy of BAE in animal models.
Early clinical data suggest BAE can lead to weight loss and improved metabolic parameters.
BAE has shown a favorable safety profile in initial investigations.

Conclusions:

BAE presents a promising, minimally invasive interventional radiology approach for obesity treatment.
Further clinical trials are warranted to establish BAE's long-term efficacy and safety.
BAE could offer a new therapeutic option for patients seeking weight management solutions.