Effect of Intravenous Total Anesthesia on Hemodynamic Changes in Renal Transplant

The objective of the transanesthetic management of renal transplant is to achieve graft function and improve its prognosis and quality of life of the patient; total intravenous anesthesia (TIVA) is an attractive alternative for the maintenance of hemodynamic stability, lower immunologic involvement, and prevention of reperfusion ischemia injury, which are fundamental in the success of the transplant. The objective of the study was to determine the effect of TIVA on hemodynamic changes in renal transplant.

We performed a retrospective observational study of patients who received transplants under TIVA from March 1, 2014, to March 31, 2019. Baseline vital signs and their variability were analyzed in addition to the times and goals of surgery and anesthesia. The statistical analysis was descriptive and inferential and with χ² test, Student t test, and Fisher exact test.

A total of 30 patients were included, and P < .001 was determined in the variability of hemodynamics during the transanesthetic period and at the end of the surgery (χ² and Student t was applied). In addition, P < .001 was obtained with a mean difference of 6.12 and CI of 5.02 to 7.22 for creatinine at 24 hours post transplant, of 2.42 and CI of 1.89 to 2.95 and P < .001 for creatinine at 48 hours, and P < .001 at 72 hours. There was spontaneous uresis in 90%.

TIVA and the use of adjuvants could be the best option for the anesthetic management of renal transplant and offers greater benefits compared with traditional management.