p62 as a therapeutic target for tumor

Area of Science:

• Cellular Biology
• Molecular Oncology
• Biochemistry

Background:

• p62/SQSTM1 (p62) is a stress-inducible protein involved in various cellular signaling pathways.
• Emerging evidence implicates p62 in the development and progression of tumors.
• p62 represents a potential therapeutic target for cancer treatment.

Purpose of the Study:

• To review the biological functions of p62 structural domains.
• To summarize bioactive molecules that target p62.
• To elucidate the relationship between p62 and tumorigenesis.

Main Methods:

• Literature review of studies on p62.
• Analysis of p62 domain functions.
• Compilation of bioactive molecules targeting p62.
• Review of research linking p62 to cancer.

Main Results:

• p62 possesses distinct structural domains that dictate its diverse cellular roles.
• Several small molecules and natural compounds have demonstrated activity against p62.
• p62 is implicated in multiple stages of tumorigenesis, including initiation, proliferation, and metastasis.

Conclusions:

• p62's multifaceted roles in cellular regulation and its involvement in cancer underscore its significance.
• Targeting p62 offers a promising therapeutic strategy for various types of cancer.
• Further research into p62 biology and targeted therapies is warranted.