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Task-specific interhemispheric hypoconnectivity in writer's cramp - An EEG study.

Nivethida Thirugnanasambandam1, Tyler Zimmerman2, Ajay S Pillai1

  • 1Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

Writer's cramp (WC) patients exhibit reduced interhemispheric alpha connectivity specifically during handwriting tasks. This finding suggests a potential new target for interventions in this task-specific dystonia.

Keywords:
EEGFocal task specific dystoniaFunctional connectivityInterhemispheric coherenceWriter’s cramp

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Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Writer's cramp (WC) is a task-specific focal dystonia affecting hand posture during writing.
  • The underlying pathophysiology, particularly its task specificity, remains incompletely understood.

Purpose of the Study:

  • To investigate the neural mechanisms contributing to the task specificity of writer's cramp using electroencephalography (EEG).
  • To explore differences in brain connectivity between WC patients and healthy controls during specific motor tasks and their imagery.

Main Methods:

  • Recruited 15 WC patients and 15 healthy controls.
  • Recorded EEG data during four tasks: handwriting, pencil sharpening, imagining handwriting, and imagining sharpening.
  • Analyzed interhemispheric connectivity in sensorimotor and premotor-parietal regions.

Main Results:

  • WC patients showed a significant reduction in interhemispheric alpha coherence in sensorimotor areas exclusively during handwriting.
  • A trend towards reduced premotor-parietal coherence was observed during motor tasks in WC patients.
  • WC patients exhibited less reduction in task-related beta spectral power compared to controls.

Conclusions:

  • The study did not confirm premotor-parietal connectivity abnormalities specific to handwriting in WC patients using the employed methods.
  • A task-specific reduction in interhemispheric alpha connectivity was identified in WC patients, though its behavioral relevance is currently unknown.
  • Interhemispheric alpha connectivity presents a potential therapeutic target for writer's cramp.