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Updated: Dec 25, 2025

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

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Rhesus Monkey Rhadinovirus Isolated from Hemangioma Tissue.

Armin Ensser¹, Koji Yasuda², William Lauer^2,3

¹Institute of Clinical and Molecular Virology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Microbiology Resource Announcements

|March 21, 2020

Summary

This summary is machine-generated.

Researchers isolated a novel rhesus monkey rhadinovirus (RRVmmu 209-07) from tumor tissue. Genomic sequencing revealed high similarity to RRV 26-95, with notable variations in the 3' genome region.

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Area of Science:

Virology
Genomics
Primate Virology

Background:

Rhesus monkey rhadinovirus (RRV) is an oncogenic gammaherpesvirus.
Understanding RRV genetic diversity is crucial for studying its pathogenesis and oncogenic potential.

Purpose of the Study:

To isolate and characterize a novel rhesus monkey rhadinovirus (RRV) isolate.
To compare the genome of the new isolate with a known RRV strain.

Main Methods:

Isolation of rhadinovirus from hemangioma tissue of a rhesus monkey.
Whole-genome sequencing of the viral isolate using Illumina-based technology.
Comparative genomic analysis with a reference RRV strain (RRV 26-95).

Main Results:

A novel rhesus monkey rhadinovirus isolate, designated RRVmmu 209-07, was successfully obtained from hemangioma tissue.
The complete genome of RRVmmu 209-07 was sequenced and analyzed.
Genomic comparison showed high overall similarity between RRVmmu 209-07 and RRV 26-95, with significant sequence divergence identified specifically in the 3' region of the genome.

Conclusions:

The characterization of RRVmmu 209-07 expands the known genetic diversity of rhesus monkey rhadinoviruses.
The identified variations in the 3' genomic region warrant further investigation into their functional implications for viral replication and pathogenesis.