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Related Experiment Video

Updated: Dec 25, 2025

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FAM13A affects body fat distribution and adipocyte function.

Mohsen Fathzadeh1,2,3, Jiehan Li1,2,3, Abhiram Rao1,4

  • 1Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Nature Communications
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

Genetic variations in Family with Sequence Similarity 13 Member A (FAM13A) influence fat distribution and insulin resistance. Lower FAM13A expression promotes smaller adipocytes and aids differentiation, impacting metabolic health.

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Area of Science:

  • Genetics
  • Metabolic Research
  • Adipose Tissue Biology

Background:

  • Genetic variations in the FAM13A locus are linked to glycemic and metabolic traits via genome-wide association studies (GWAS).
  • FAM13A alleles correlate with altered FAM13A expression in subcutaneous adipose tissue (SAT) and insulin resistance phenotypes in humans.

Purpose of the Study:

  • To investigate the functional role of FAM13A in adipocyte differentiation and body fat distribution.
  • To elucidate the mechanism by which FAM13A genetic variants affect metabolic traits.

Main Methods:

  • Analysis of human genetic data and subcutaneous adipose tissue samples.
  • In vitro studies using human adipocyte models with FAM13A knockdown.
  • In vivo studies using Fam13a knockout mice subjected to a high-fat diet.

Main Results:

  • Human FAM13A alleles are associated with increased SAT expression, higher waist-to-hip ratio, elevated fasting insulin, and lower body fat.
  • FAM13A knockdown in human preadipocytes accelerated adipocyte differentiation.
  • Fam13a knockout mice exhibited a reduced visceral to subcutaneous fat ratio and a shift towards smaller subcutaneous adipocytes with enhanced adipogenic potential after high-fat diet.

Conclusions:

  • GWAS-associated variants in the FAM13A locus modulate adipose FAM13A expression.
  • FAM13A plays a regulatory role in adipocyte differentiation and influences body fat distribution.
  • These findings link FAM13A to metabolic health and insulin resistance through its effects on adipose tissue characteristics.