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In-line filtration in very preterm neonates: a randomized controlled trial
Anne-Laure Virlouvet1,2, Julien Pansiot2, Artemis Toumazi3
1Assistance Publique-Hôpitaux de Paris, Neonatal intensive care unit, Robert Debré children's hospital, Paris, France.
Scientific Reports
|March 21, 2020
Summary
In-line filtration did not significantly reduce inflammatory markers or complications in very preterm infants. This study suggests current practices may not benefit this vulnerable population.
Area of Science:
- Neonatal Medicine
- Pediatric Critical Care
- Clinical Research
Background:
- In-line filtration is common for critically-ill infants to prevent micro-particle infusion.
- Its efficacy in very preterm neonates, particularly regarding inflammatory responses, requires further investigation.
Purpose of the Study:
- To evaluate the impact of in-line filtration on pro-inflammatory cytokine levels in very preterm infants.
- To assess the effect of in-line filtration on major neonatal complications.
Main Methods:
- A randomized controlled trial involving 146 very preterm infants.
- Infants were assigned to either in-line filtration or standard care.
- Pro-inflammatory cytokine serum concentrations were measured on days 3 and 8; neonatal complications were secondary outcomes.
Main Results:
- No statistically significant difference in the change of pro-inflammatory cytokine concentrations (over 20%) between groups.
- Incidences of most neonatal complications were similar between the in-line filtration and control groups.
- Both intent-to-treat and per-protocol analyses showed no significant benefit.
Conclusions:
- In-line filtration did not demonstrate a beneficial effect on inflammatory response syndrome or neonatal morbidities in very preterm infants.
- Findings suggest that the benefits of in-line filtration in this population are not evident based on current inflammatory and morbidity markers.
- Interpretation of these data should consider local standards for infusion preparation and central line management.
