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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Updated: Dec 25, 2025

Consensus Brain-derived Protein, Extraction Protocol for the Study of Human and Murine Brain Proteome Using Both 2D-DIGE and Mini 2DE Immunoblotting
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Decrease in 130 kDa- amyloid protein precursor protein (APP) and APP protein ratio in schizophrenia platelets.

E B Tereshkina1, I S Boksha2, T A Prokhorova1

  • 1Mental Health Research Centre, Moscow, Russia.

Neuroscience Letters
|March 21, 2020
PubMed
Summary

Schizophrenia patients show altered amyloid precursor protein (APP) metabolism in platelets, with reduced 130 kDa-APP and APP ratio (APPr). Age-related changes in APP were also observed, suggesting peripheral APP alterations in schizophrenia.

Keywords:
APPAPPrBeta amyloid precursor proteinPlateletsSchizophrenia

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Cognitive dysfunction is a core feature of schizophrenia.
  • The underlying molecular mechanisms of cognitive deficits in schizophrenia are not well understood.
  • Amyloid precursor protein (APP) plays a role in neuronal function and its dysregulation is implicated in various neurological disorders.

Purpose of the Study:

  • To investigate alterations in amyloid precursor protein (APP) metabolism in peripheral platelets of individuals with acute schizophrenia.
  • To explore the relationship between APP changes and cognitive function in schizophrenia.

Main Methods:

  • Analysis of APP in platelets from 24 acute schizophrenia patients and 20 healthy controls using ECL-immunoblotting.
  • Quantification of specific APP molecular masses (~130 kDa, ~110 kDa, ~100 kDa) and the APP ratio (APPr).

Main Results:

  • Significantly reduced intensity of 130 kDa-APP and APPr in schizophrenia patients compared to controls.
  • Age-associated decreases in 130 kDa-APP, ~110 kDa-APP, and APPr were observed in patients, but not in controls.

Conclusions:

  • Peripheral APP metabolism is altered in individuals with schizophrenia.
  • These findings suggest a potential role for APP in the pathophysiology of schizophrenia and its cognitive impairments.
  • Further research with larger cohorts and detailed cognitive assessments is warranted to elucidate APP's role in schizophrenia progression and outcomes.