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Renal clearable nanocarriers: Overcoming the physiological barriers for precise drug delivery and clearance

Chuanqi Peng1, Yingyu Huang1, Jie Zheng1

  • 1Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 21, 2020
PubMed

Insights

Renal clearable nanocarriers improve cancer drug delivery by enhancing tumor penetration and reducing side effects. These novel drug delivery systems (DDSs) also aid in body elimination of non-targeted drugs.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Clinical translation of cancer nanomedicines faces physiological barriers.
  • Understanding nano-bio interactions is crucial for overcoming these challenges.
  • Development of novel nanocarriers is needed to address limitations in tumor microenvironment penetration and systemic toxicity.

Purpose of the Study:

  • To introduce and explore the potential of renal clearable nanocarriers as an advanced drug delivery system (DDS).
  • To highlight how these nanocarriers can overcome key barriers in cancer nanomedicine translation.
  • To discuss the benefits of renal clearable DDSs for improving therapeutic efficacy and reducing side effects.

Main Methods:

  • The study focuses on the design principles and functional characteristics of renal clearable nanocarriers.
  • It examines their interaction with the biological system, including tumor penetration and macrophage uptake.
  • The elimination pathways and biodistribution of these nanocarriers are considered.

Main Results:

  • Renal clearable nanocarriers facilitate rapid drug penetration into tumor cores.
  • They effectively escape macrophage uptake, preventing clearance from circulation.
  • These nanocarriers enhance the body's elimination of non-targeted anticancer drugs, improving safety.
  • Improved therapeutic efficacies and reduced side effects of anticancer drugs are achieved.

Conclusions:

  • Renal clearable nanocarriers represent a promising advancement in cancer drug delivery.
  • They offer a strategy to enhance tumor-specific drug accumulation and minimize systemic toxicity.
  • Future applications may extend to diagnostic agents, gene editing, and immunotherapy.
Keywords:
CancerDrug deliveryNanocarriersNanomedicineNanoparticlePhysiological barriersRenal clearance

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