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Progresses on bacterial secretomes enlighten research on Mycoplasma secretome

Muhammad Zubair1, Farhan Anwar Khan2, Harish Menghwar1

  • 1The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Microbial Pathogenesis
|March 21, 2020
PubMed

Insights

Bacterial secretomes, proteins secreted by bacteria, are crucial for pathogenesis and communication. Studying these secretomes aids in identifying novel antigens for diagnostics and vaccine development against bacterial infections.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Immunology

Background:

  • Bacterial secretomes encompass proteins released extracellularly, playing key roles in virulence and intercellular communication.
  • Secreted proteins, sometimes forming extracellular vesicles (EVs) or outer membrane vesicles (OMVs), are essential for bacterial pathogenesis.
  • These proteins are translocated via Sec and Tat pathways into the periplasm.

Purpose of the Study:

  • To review secretome studies of pathogenic bacteria in humans and animals.
  • To discuss general bacterial secretion mechanisms.
  • To highlight approaches and challenges in studying the secretome of Mycoplasma sp.

Main Methods:

  • Literature review of existing secretome studies.
  • Analysis of bacterial secretion pathways (Sec and Tat).
  • Examination of techniques and hurdles in secretomic analysis, particularly for Mycoplasma.

Main Results:

  • Secreted proteins are significant virulence factors and mediators of bacterial pathogenesis.
  • Secretomes contain potential diagnostic markers and antigenic targets for vaccine design.
  • Research in bacterial secretomics is expanding due to its direct link to infectious diseases.

Conclusions:

  • Secretome analysis offers valuable insights into bacterial pathogenicity.
  • Identified antigens from secretomes can lead to the development of novel vaccines and diagnostics.
  • Further research into bacterial secretomes, especially from challenging organisms like Mycoplasma, is warranted.
Keywords:
AntigensBacteriaExtracellular vesiclesMycoplasmaPathogenesisSecretomes

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