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Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
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Reduced Complexity in Stroke with Motor Deficits: A Resting-State fMRI Study
Liuke Liang1, Rongliang Hu2, Xuemao Luo3
1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China.
Neuroscience
|March 21, 2020
Summary
Stroke patients show reduced brain complexity (BEN) in motor areas compared to controls. Brain entropy may help evaluate motor deficits after stroke.
Area of Science:
- Neuroscience
- Medical Imaging
Background:
- Brain entropy (BEN) quantifies brain complexity, with alterations observed in various brain disorders.
- Changes in brain complexity following stroke, a common cerebrovascular disease, are not well understood.
Purpose of the Study:
- To investigate alterations in brain complexity using BEN in stroke patients with motor deficits.
- To explore the relationship between BEN and motor impairment severity.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was used in 20 stroke patients and 19 healthy controls.
- Sample entropy (SampEn) was applied to generate BEN maps for each participant.
- Correlation analysis was performed between BEN values and Fugl-Meyer Assessment (FMA) scores.
Main Results:
- Stroke patients exhibited significantly lower BEN values in the contralesional precentral gyrus (preCG), bilateral dorsolateral frontal gyrus (SFGdor), and bilateral supplementary motor area (SMA) compared to controls.
- Positive correlations were found between BEN values and FMA scores in the ipsilesional SFGdor and SMA.
- Mutual information independence was observed between BEN and regional homogeneity (ReHo) or amplitude of low-frequency fluctuations (ALFF) in stroke patients.
Conclusions:
- Brain complexity is impacted by stroke, particularly in motor-related areas.
- BEN may serve as a complementary neuroimaging biomarker for assessing motor deficits post-stroke.
