Related Experiment Video

Updated: Dec 25, 2025

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.7K

Current Status of Septic Cardiomyopathy: Basic Science and Clinical Progress

Huan Lin1, Wenting Wang1, Madeline Lee2

  • 1Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Frontiers in Pharmacology
|March 21, 2020
PubMed

Insights

Septic cardiomyopathy (SCM), a sepsis-induced heart failure, lacks clear diagnostic criteria. This review summarizes recent findings on SCM pathogenesis, diagnosis, and treatment to advance understanding and patient care.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Septic cardiomyopathy (SCM) is a critical complication of sepsis, characterized by cardiovascular dysfunction.
  • Despite advancements, consistent diagnostic criteria for SCM remain elusive.
  • Understanding SCM's pathophysiology is crucial for effective management.

Purpose of the Study:

  • To review recent literature (past 5 years) on septic cardiomyopathy.
  • To provide an overview of current knowledge regarding SCM pathogenesis.
  • To summarize contemporary diagnostic and therapeutic strategies for SCM.

Main Methods:

  • Systematic literature search of major scientific databases.
  • Inclusion of studies published within the last five years.
  • Synthesis of data on SCM pathogenesis, diagnosis, and treatment.

Main Results:

  • Several hypotheses on the pathogenic mechanisms of SCM have been proposed.
  • Progress has been made in diagnostic approaches, though standardization is lacking.
  • Current treatment strategies are evolving based on emerging pathophysiological insights.

Conclusions:

  • Septic cardiomyopathy presents a complex challenge in sepsis management.
  • Further research is needed to refine diagnostic criteria and therapeutic interventions for SCM.
  • A comprehensive understanding of SCM pathogenesis is essential for improving outcomes.

Keywords:
diagnosisheart failureleft ventricular ejection fractionpathogenesissepsisseptic cardiomyopathytreatment

More Related Videos

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.7K
Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

8.0K

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
237
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
415
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
289
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
350
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
370
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
233