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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Tip of the iceberg: roles of circRNAs in hematological malignancies

Shan-Shan Guo1, Bi-Xia Li2, Duo-Bing Zou3

  • 1Ningbo Hospital, School of Medicine, Zhejiang University Ningbo, Zhejiang, PR China.

American Journal of Cancer Research
|March 21, 2020
PubMed

Insights

Circular RNAs (circRNAs) are novel RNA molecules with crucial roles in disease. This review summarizes circRNA functions in hematopoiesis and hematological malignancies, highlighting their potential as biomarkers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules formed by back-splicing.
  • Emerging evidence indicates circRNAs are vital in disease development and serve as potential biomarkers.
  • Knowledge regarding circRNAs in hematological malignancies remains limited.

Purpose of the Study:

  • To summarize the biogenesis, categories, characteristics, and functions of circRNAs.
  • To elucidate the specific roles of circRNAs in hematopoiesis.
  • To explore the involvement of circRNAs in hematological malignancies.

Main Methods:

  • Literature review and synthesis of existing research on circRNAs.
  • Analysis of studies focusing on circRNA biogenesis and function.
  • Compilation of data on circRNAs in the context of blood formation and cancers.

Main Results:

  • CircRNAs exhibit diverse biogenesis pathways and structural characteristics.
  • CircRNAs play regulatory roles in gene expression and cellular processes.
  • Specific circRNAs are implicated in the pathogenesis of various hematological malignancies.

Conclusions:

  • CircRNAs represent a significant area of research with implications for understanding blood disorders.
  • Further investigation into circRNAs could lead to novel diagnostic and therapeutic strategies for hematological cancers.
  • This review provides a comprehensive overview of circRNAs in hematopoiesis and hematological malignancies.
Keywords:
acute myeloid leukemiachronic myeloid leukemiacircRNAhematopoiesislymphoid malignancies

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