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Updated: Dec 25, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
Regulation of cGAS-Mediated Immune Responses and Immunotherapy
Abdullah F U H Saeed1,2,3,4, Xinglin Ruan5, Hongxin Guan1,2
1The Key Laboratory of Innate Immune Biology of Fujian Province Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation Biomedical Research Center of South China Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education College of Life Sciences Fujian Normal University Fuzhou 350117 China.
Abstract:
Early detection of infectious nucleic acids released from invading pathogens by the innate immune system is critical for immune defense. Detection of these nucleic acids by host immune sensors and regulation of DNA sensing pathways have been significant interests in the past years. Here, current understandings of evolutionarily conserved DNA sensing cyclic GMP-AMP (cGAMP) synthase (cGAS) are highlighted. Precise activation and tight regulation of cGAS are vital in appropriate innate immune responses, senescence, tumorigenesis and immunotherapy, and autoimmunity. Hence, substantial insights into cytosolic DNA sensing and immunotherapy of indispensable cytosolic sensors have been detailed to extend limited knowledge available thus far. This Review offers a critical, in-depth understanding of cGAS regulation, cytosolic DNA sensing, and currently established therapeutic approaches of essential cytosolic immune agents for improved human health.
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