Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart conduction system: a neural crest derivative?

L Gorza1, S Schiaffino, M Vitadello

  • 1Institute of General Pathology, University of Padova, Italy.

Brain Research
|August 9, 1988
PubMed
Summary

Rabbit heart conduction tissue cells may originate from neural crest cells. These cells migrate from the branchial arches and express neurofilament middle subunit (NF-M) and neural crest markers during embryonic development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transthyretin variant cerebral amyloid angiopathy fulfilling the modified Boston criteria: Retrospective data from the Bicêtre hospital cohort.

Revue neurologique·2025
Same author

The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state.

Nature communications·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

Publisher Correction: Burning plasma achieved in inertial fusion.

Nature·2022
Same author

Burning plasma achieved in inertial fusion.

Nature·2022

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Cardiology

Background:

  • The origin of cardiac conduction system cells remains a key question in cardiovascular development.
  • Neurofilaments are crucial components of the neuronal cytoskeleton, but their presence in cardiac tissue is not well understood.

Purpose of the Study:

  • To investigate the potential origin of cardiac conduction tissue cells.
  • To identify specific molecular markers expressed by these cells during development.

Main Methods:

  • Immunohistochemical analysis using anti-neurofilament monoclonal antibody iC8 and HNK-1 antibody.
  • Electrophoretic analysis of cytoskeletal proteins.
  • Examination of embryonic rabbit heart and branchial arch tissues at the 11-day stage.

Main Results:

  • Cardiac conduction system fibers in adult and developing rabbits express a protein similar to neurofilament middle subunit (NF-M).
  • In 11-day embryos, cardiac muscle cells express the neural crest marker HNK-1.
  • Cells in the 4th branchial arch, of neural crest origin, co-express sarcomeric myosin heavy chain with iC8 and HNK-1 immunoreactivity when near the developing atrium.

Conclusions:

  • The study suggests that conduction tissue cells in the rabbit heart originate from neural crest-derived cells.
  • These cells likely migrate from the branchial arches into the developing heart during embryogenesis.

Related Experiment Videos