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A study of ionic conductances involved in plateau potential activity in putative vasopressinergic neurons in primary
P Legendre1, D A Poulain, J D Vincent
1I.N.S.E.R.M. U.176, Université de Bordeaux II, France.
Brain Research
|August 9, 1988
Abstract:
Vasopressin neurons in hypothalamic cell culture display regenerative calcium-dependent plateau potentials. The present study was undertaken to investigate the mechanisms underlying their time course and periodicity. Intracellular recordings showed that the duration of the plateaux was controlled by a progressive activation of a voltage- and calcium-dependent potassium conductance, but not by a progressive inactivation of calcium conductances. The refractory period appeared to be due to a calcium-dependent potassium conductance activated by membrane potential depolarization.