Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship between foveal anatomy and retinal function in oculocutaneous albinism.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same author

Small Copy Number Neutral Intrachromosomal Translocation of PAX6 and Aniridia.

JAMA ophthalmology·2026
Same author

The human fovea.

Handbook of clinical neurology·2026
Same author

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.

bioRxiv : the preprint server for biology·2026
Same author

A Blinded Analysis of Quality and Fidelity in Orthopaedic Patient Education Materials Simplified by ChatGPT and Humans.

The Journal of bone and joint surgery. American volume·2026
Same author

Aetiology, characteristics and workup of early onset high myopia.

The British journal of ophthalmology·2026

Related Experiment Video

Updated: Dec 25, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.6K

Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.

Erica N Woertz1, Bisola S Omoba1, Taylor M Dunn1

  • 1,.

Investigative Ophthalmology & Visual Science
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

Albinism alters retinal topography, specifically in the ganglion cell layer (GCL) and inner plexiform layer (IPL). These changes suggest differences in retinal ganglion cell distribution, impacting foveal development and function.

More Related Videos

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.5K

Related Experiment Videos

Last Updated: Dec 25, 2025

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.6K
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.5K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Albinism is a genetic disorder characterized by reduced pigmentation in the eyes, skin, and hair.
  • Retinal structure, particularly the ganglion cell layer (GCL) and inner plexiform layer (IPL), plays a crucial role in visual processing.
  • Previous studies have not fully elucidated the topographical organization of the GCL and IPL in albinism.

Purpose of the Study:

  • To investigate whether the topography of the ganglion cell layer (GCL) and inner plexiform layer (IPL) is altered in individuals with albinism.
  • To compare GCL and IPL topography between participants with albinism and healthy controls.

Main Methods:

  • Optical coherence tomography (OCT) scans were analyzed from 30 participants with albinism and 25 controls.
  • Automated and manual segmentation techniques were used to measure GCL and IPL thickness and area under the curve (AUC) within 2.5 mm of the fovea.
  • Nasal-temporal and superior-inferior asymmetry ratios were calculated to assess topographical organization.

Main Results:

  • While overall GCL and IPL AUC were similar between groups, significant topographical differences were observed.
  • Participants with albinism exhibited greater nasal-temporal asymmetry in both the GCL and IPL compared to controls.
  • The GCL constituted a smaller percentage of the combined GCL and IPL in albinism compared to controls.

Conclusions:

  • Retinal GCL and IPL topography show greater structural variability than previously recognized.
  • Altered GCL and IPL topography in albinism indicates differences in the spatial distribution of retinal ganglion cells.
  • These findings offer insights into foveal development and structure-function relationships in conditions like foveal hypoplasia.