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The Current Status of the Production and Supply of Gallium-68
1Laboratory for Translational Research in Imaging Pharmaceuticals, Department of Radiology, The Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, Ohio.
Abstract:
Gallium-68 (68Ga) is an important radionuclide due to its successful use in the clinic. Currently, 68Ga is produced and supplied by using germanium-68/Gallium-68 (68Ge/68Ga) generator systems in the preclinical and clinical environments. Until recently, the supply of 68Ge/68Ga generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of 68Ga by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of 68Ga radionuclide.
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