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Updated: Dec 25, 2025

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The relationship between HSP60 gene polymorphisms and susceptibility to atherosclerosis

B-H Liao1, Z-L Xu, F Gao

  • 1Department of Cardiology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, China. 78249073@qq.com.

European Review for Medical and Pharmacological Sciences
|March 21, 2020
PubMed

Insights

Heat shock protein 60 (HSP60) gene polymorphisms are linked to atherosclerosis. Specific HSP60 gene variations correlate with the disease's pathological grade and incidence rate.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Background:

  • Atherosclerosis is a significant cardiovascular disease.
  • Heat shock protein 60 (HSP60) plays a role in cellular stress responses.
  • Genetic variations may influence atherosclerosis susceptibility.

Purpose of the Study:

  • To investigate the association between HSP60 gene polymorphisms and atherosclerosis.
  • To determine if specific HSP60 gene loci (rs2340690 and rs788016) are risk factors for atherosclerosis.

Main Methods:

  • Genotyping of HSP60 gene loci rs2340690 and rs788016 using TaqMan probe technology.
  • Case-control study involving 160 atherosclerosis patients and 200 healthy controls.
  • Statistical analysis of genotype frequencies and their correlation with atherosclerosis incidence and pathological grade.

Main Results:

  • No significant difference in genotype frequencies between atherosclerosis patients and controls.
  • HSP60 rs2340690 and rs788016 showed no association with atherosclerosis incidence across genetic models.
  • A higher proportion of GG genotype at rs2340690 was observed in severe atherosclerosis (grade IV).
  • Carriage of rs788016 A allele was more frequent in atherosclerosis patients.
  • Combined genotypes (rs2340690 G and rs788016 A) were associated with increased odds of atherosclerosis (OR=1.721, p=0.049).

Conclusions:

  • HSP60 gene polymorphisms are correlated with the pathological grade of atherosclerosis.
  • Specific HSP60 gene variations are associated with atherosclerosis incidence.
  • Findings suggest HSP60 gene polymorphisms as potential biomarkers for atherosclerosis risk and severity.
Abstract

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