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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Related Experiment Video

Updated: Dec 25, 2025

Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
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Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities

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PRIRATE 2020 guidelines for reporting randomized trials in Endodontics: a consensus-based development.

V Nagendrababu1, H F Duncan2, L Bjørndal3

  • 1Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

International Endodontic Journal
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

New Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines were developed to improve reporting quality in endodontic randomized clinical trials. These guidelines ensure comprehensive and standardized reporting for better evidence-based dentistry.

Keywords:
Endodonticsconsensusguidelinesrandomized controlled trial

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Area of Science:

  • Dental research
  • Clinical trial methodology
  • Evidence-based dentistry

Background:

  • Randomized clinical trials (RCTs) are crucial for evidence-based healthcare.
  • Accurate and reliable reporting of RCTs in Endodontology is essential for clinical decision-making.
  • Existing guidelines may not fully address the specific needs of endodontic research.

Purpose of the Study:

  • To develop and validate reporting guidelines specifically for randomized clinical trials in Endodontology.
  • To enhance the quality and transparency of published endodontic RCTs.
  • To introduce the Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines.

Main Methods:

  • A consensus-based methodology was employed, involving a steering committee, a Delphi process, and a face-to-face meeting.
  • The development was informed by the Consolidated Standards of Reporting Trials (CONSORT) and Clinical and Laboratory Images in Publications (CLIP) principles.
  • Guidelines were refined through expert consensus and piloting by authors.

Main Results:

  • The PRIRATE 2020 guidelines include a checklist with 11 sections and 58 items.
  • A flowchart detailing the trial process is also part of the guidelines.
  • Consensus was achieved among 30 Delphi participants and confirmed in a face-to-face meeting.

Conclusions:

  • The PRIRATE 2020 guidelines provide a comprehensive framework for reporting endodontic RCTs.
  • Adherence to these guidelines will improve the quality and consistency of research reporting in Endodontology.
  • These guidelines are essential for authors preparing manuscripts for endodontic randomized clinical trials.