How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
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Updated: Dec 25, 2025

Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Sajad Yaghoubi1, Hamid Najminejad2, Mehran Dabaghian3
1Department of Clinical Microbiology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Abstract:
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.
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