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Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice
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Pain Sensitivity Modifies Risk of Injury-Related Temporomandibular Disorder.

S Sharma1,2, R Ohrbach2, R B Fillingim3

  • 1Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, Malmö, Skåne, Sweden.

Journal of Dental Research
|March 21, 2020
PubMed
Summary
This summary is machine-generated.

Jaw injuries, including those from yawning, significantly increase the risk of developing painful temporomandibular disorder (TMD). This risk is further amplified in individuals with heightened sensitivity to heat pain.

Keywords:
central sensitizationincidencepain thresholdprospective studiesrisk factorstemporomandibular joint disorders

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Area of Science:

  • Orofacial Pain Research
  • Epidemiology
  • Pain Sensitivity Studies

Background:

  • Temporomandibular disorder (TMD) is a prevalent condition affecting the jaw joint and muscles.
  • Identifying risk factors for developing painful TMD is crucial for prevention and management.

Purpose of the Study:

  • To evaluate the contribution of jaw injury and experimental pain sensitivity to the risk of incident painful TMD.
  • To investigate the association between different types of jaw injuries and TMD onset.

Main Methods:

  • Prospective cohort study (Orofacial Pain: Prospective Evaluation and Risk Assessment - OPPERA) with nested case-control analysis.
  • Quantitative sensory testing to measure pain sensitivity at baseline.
  • Quarterly questionnaires to monitor jaw injuries and TMD onset over up to 5 years.

Main Results:

  • Jaw injuries, particularly extrinsic events, sustained opening, and yawning, were significantly associated with increased TMD incidence.
  • Both single and multiple injuries elevated the risk of painful TMD compared to non-injurious events.
  • The risk of TMD associated with jaw injury was amplified in individuals with higher baseline heat pain sensitivity.

Conclusions:

  • Jaw injury is a strong predictor of developing painful TMD.
  • Pre-existing heightened pain sensitivity, especially to heat, exacerbates the risk conferred by jaw injury.
  • Seemingly minor injuries like those from yawning warrant consideration in assessing TMD prognosis.