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Glucose ligand modififed thermally activated delayed fluorescence targeted nanoprobe for malignant cells imaging
Wenlei Zhao1, Hongliang Wei1, Fengjie Liu1
1Department of Radiology, Yantai Yuhuangding Hospital, The Affiliated Hospital of Qingdao University, Yantai, Shandong, 264000, PR China.
Abstract:
Probes with long lifetime fluorescent emission are highly desirable for time-resolved fluorescence imaging to eliminate the interference from short-lived auto-fluorescence. Aromatic-imide-based thermally activated delayed fluorescence material TADF compound with high external quantum efficiency was encapsulated with Glucose-PEG2000-DSPE amphiphilic copolymer to prepare nanoprobe micelles. Glucose-PEG2000-DSPE TADF (GPDT) Micelles had good biocompatibility, biodegradability, less toxicity, and they could be efficiently transported by over expressed GLUT1 on tumor cell membrane, then efficiently targeted lysosome of HepG2 cells. GPDT Micelles had great clinical application and research development value, and be suitable for the application and popularization in fluorescence imaging technology, especially time-resolved fluorescent imaging in living cells.
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