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Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

Johannes U Lauenstein1, Michael J Scherm1, Atul Udgata1

  • 1Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom; and.

Journal of Immunology (Baltimore, Md. : 1950)
|March 22, 2020
PubMed
Summary

B cell adaptor protein (BCAP) negatively regulates Toll-like receptor (TLR) signaling through its TIG/IPT domain. This domain mediates indirect dimerization, crucial for inhibiting inflammatory pathways in immune cells.

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