Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.2K

Pediatric cardiac waitlist mortality-Still too high

Susan W Denfield1, Estela Azeka2, Bibhuti Das3

  • 1Division of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

Pediatric Transplantation
|March 22, 2020
PubMed

Insights

Pediatric heart transplant waitlist mortality is high due to donor shortages. Identifying high-risk children and acceptable marginal donors is crucial for reducing deaths in children awaiting heart transplants.

Area of Science:

  • Cardiology
  • Pediatric Medicine
  • Transplantation

Background:

  • Pediatric heart transplantation is a standard treatment for end-stage cardiac disease in children.
  • The demand for pediatric heart transplants consistently outstrips donor availability.
  • This disparity leads to significant waitlist mortality among children needing cardiac transplants.

Purpose of the Study:

  • To review pediatric studies on heart transplant waitlist mortality globally over the past 15 years.
  • To identify subgroups of children at highest risk of mortality while awaiting transplant.
  • To discuss strategies for improving the utilization of marginal donors and reducing waitlist deaths.

Main Methods:

  • Systematic review of pediatric studies published in the last 15 years.
  • Focus on research concerning waitlist mortality in pediatric heart transplant recipients.
  • Analysis of data across different subgroups of children awaiting heart transplants worldwide.

Main Results:

  • The review highlights significant waitlist mortality in children awaiting heart transplants.
  • Certain pediatric subgroups face higher risks of mortality.
  • The need for better donor allocation and recipient selection strategies is evident.

Conclusions:

  • Reducing waitlist mortality in pediatric heart transplantation requires a multi-faceted approach.
  • Prioritizing recipients most in need and carefully evaluating marginal donors are key strategies.
  • Further research and optimized clinical practices are essential to improve outcomes for children awaiting heart transplants.

Keywords:
childrenheart transplantmortalitywaitlist

More Related Videos

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

7.1K
A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position11:20

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Published on: April 1, 2022

3.4K

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
204
Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
460
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
237
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
153
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
445
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
247