Related Experiment Video

Updated: Dec 25, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.7K

Wheezing in Preschool Children and Total IgE Levels: A Birth Cohort Study

Kana Ram Jat1, Prawin Kumar1, Aparna Mukherjee1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Indian Pediatrics
|March 22, 2020
PubMed

Insights

Total immunoglobulin E (IgE) levels rise with age in Indian preschool children. This study found no significant difference in total IgE levels between children who experienced wheezing and those who did not.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Health
  • Epidemiology

Background:

  • Wheezing is a common respiratory symptom in preschool children.
  • Total immunoglobulin E (IgE) is a marker often associated with allergic conditions.
  • Understanding the relationship between IgE levels and wheezing is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the association between total IgE levels and the occurrence of wheezing episodes in preschool children in India.
  • To determine if elevated total IgE levels correlate with increased wheezing frequency.

Main Methods:

  • Prospective birth cohort study design.
  • Total IgE levels measured at enrollment, 1 year, and 2 years of age.
  • Correlation analysis between total IgE levels and reported wheezing episodes up to age three.

Main Results:

  • A total of 310 children were enrolled in the study.
  • Total IgE levels demonstrated a significant increase with age (P<0.001).
  • No significant difference in median total IgE levels was observed between children with and without wheezing at one year (P=0.39) and two years of age (P=0.92).

Conclusions:

  • Total IgE levels increase with age in preschool children.
  • Total IgE levels do not appear to be a differentiating factor for wheezing in this population.
  • Further research may be needed to explore other biomarkers or factors associated with childhood wheezing.
Abstract

More Related Videos

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.4K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.8K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
31.7K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.2K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K