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Review and Prospect of Pathological Features of Corona Virus Disease

H J Wang1, S H Du1, X Yue1

  • 1School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.

Fa Yi Xue Za Zhi
|March 22, 2020
PubMed

Insights

Coronavirus outbreaks, including COVID-19, SARS, and MERS, cause viral pneumonia. This review compares autopsy findings from these three diseases to improve understanding of COVID-19 pathology.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Public Health

Background:

  • Coronaviruses have caused significant global epidemics since 2003, including SARS, MERS, and COVID-19.
  • COVID-19, caused by coronavirus, has severely impacted global health and lives since its emergence in December 2019.
  • Current pathological diagnosis for COVID-19 remains limited, with insufficient awareness of its characteristics among medical professionals.

Purpose of the Study:

  • To comprehensively review and compare the pathological features of SARS, MERS, and COVID-19 based on autopsy findings.
  • To provide a reference for analyzing the pathological changes associated with COVID-19.
  • To enhance the understanding of coronavirus-induced viral pneumonia.

Main Methods:

  • Literature review of autopsy findings from published cases of SARS, MERS, and COVID-19.
  • Comparative analysis of pathological characteristics across the three coronaviruses.
  • Synthesis of information on organ-specific pathological changes.

Main Results:

  • SARS, MERS, and COVID-19 share similarities in causing viral pneumonia.
  • Distinct and common pathological features are observed across the three diseases.
  • Autopsy studies reveal significant lung damage and systemic effects.

Conclusions:

  • Understanding the comparative pathology of SARS, MERS, and COVID-19 is crucial for accurate diagnosis and management of COVID-19.
  • Further research into COVID-19 pathology is needed to address diagnostic deficiencies.
  • This review serves as a foundational resource for clinicians and researchers studying coronavirus-related diseases.

Keywords:
forensic pathology; autopsy; coronavirus; corona virus disease 2019 （COVID-19）; severe acute respiratory syndrome （SARS）; Middle East respiratory syndrome （MERS）; review

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