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A new look at transudation: the apocrine connection
R Farkaš1, M Beňo, D Beňová-Liszeková
1Laboratory of Developmental Genetics, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovak Republic. ueenfark@savba.sk.
Transcellular trafficking, including transcytosis and transudation, involves molecule transport across cells. While sharing initial steps, they differ in the re-secretion process, with transudation utilizing apocrine secretion.
Area of Science:
- Cell Biology
- Molecular Transport
Background:
- Transcellular trafficking involves molecule transport across cell interiors.
- The terms transcytosis and transudation have been historically used interchangeably.
Purpose of the Study:
- To clarify the distinctions between transcytosis and transudation.
- To define transudation as a distinct cellular transport mechanism.
Main Methods:
- Comparative analysis of molecular trafficking pathways.
- Review of recent studies on protein re-secretion mechanisms.
Main Results:
- Transcytosis and transudation share similarities in cargo internalization and endosomal sorting.
- A key difference lies in the re-secretion process: transudation involves massive release via non-canonical apocrine secretion, distinct from exocytosis.
Conclusions:
- Transcellular trafficking encompasses both transcytosis and transudation.
- Transudation is characterized by apocrine secretion of endocytosed material from the apical pole of specialized cells.
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