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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Related Experiment Video

Updated: Dec 25, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Soft tissue sarcomas in infants. Case series.

Gonzalo Magno1, José I Albergo2, Patricia Streitenberger2

  • 1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. gonzalo.magno@hospitalitaliano.org.ar.

Archivos Argentinos De Pediatria
|March 22, 2020
PubMed
Summary

Pediatric soft tissue sarcomas in children under two years old are rare. Combined surgical treatment and chemotherapy offer a 100% survival rate, but limb salvage surgery has a high local recurrence rate.

Keywords:
infantsrhabdomyosarcomasoft tissue sarcomassurgery

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Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Pediatric Sarcomas

Background:

  • Soft tissue sarcomas (STS) are rare in children under two years old.
  • This study focuses on a small cohort of very young patients diagnosed with STS.

Purpose of the Study:

  • To analyze clinical and oncologic outcomes in patients under two years of age with STS.
  • To evaluate the effectiveness of different treatment modalities and identify prognostic factors.

Main Methods:

  • Retrospective analysis of 6 patients under two years old diagnosed with STS between 2007 and 2017.
  • Evaluation of treatment strategies including surgery (limb salvage vs. amputation) and adjuvant chemotherapy.
  • Assessment of outcomes such as survival rates and local recurrence.

Main Results:

  • Fibrosarcoma was the most frequent diagnosis (n=4).
  • The 24-month survival rate was 100%.
  • Two patients experienced local recurrence within 24 months, particularly after limb salvage surgery.

Conclusions:

  • Combined surgical treatment and chemotherapy represent the optimal therapeutic approach for very young patients with STS.
  • Limb salvage surgery, while feasible, is associated with a high rate of local recurrence in this pediatric population.