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Updated: Dec 25, 2025
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Soft tissue sarcomas in infants. Case series
Gonzalo Magno1, José I Albergo2, Patricia Streitenberger2
1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. gonzalo.magno@hospitalitaliano.org.ar.
Insights
Pediatric soft tissue sarcomas in children under two years old are rare. Combined surgical treatment and chemotherapy offer a 100% survival rate, but limb salvage surgery has a high local recurrence rate.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Pediatric Sarcomas
Background:
- Soft tissue sarcomas (STS) are rare in children under two years old.
- This study focuses on a small cohort of very young patients diagnosed with STS.
Purpose of the Study:
- To analyze clinical and oncologic outcomes in patients under two years of age with STS.
- To evaluate the effectiveness of different treatment modalities and identify prognostic factors.
Main Methods:
- Retrospective analysis of 6 patients under two years old diagnosed with STS between 2007 and 2017.
- Evaluation of treatment strategies including surgery (limb salvage vs. amputation) and adjuvant chemotherapy.
- Assessment of outcomes such as survival rates and local recurrence.
Main Results:
- Fibrosarcoma was the most frequent diagnosis (n=4).
- The 24-month survival rate was 100%.
- Two patients experienced local recurrence within 24 months, particularly after limb salvage surgery.
Conclusions:
- Combined surgical treatment and chemotherapy represent the optimal therapeutic approach for very young patients with STS.
- Limb salvage surgery, while feasible, is associated with a high rate of local recurrence in this pediatric population.
Abstract:
Soft tissue sarcomas in children under 2 years of age are infrequent. During 2007-2017, a total of 445 patients diagnosed with soft tissue sarcomas were treated at our institution, 6(0.5%) were under 2 years. We analysed clinical and oncologic outcomes in this select group. The mean age of diagnosis was 15 months. Four patients were male and 2 female. The mean follow-up time was 29 months. Fibrosarcoma (n = 4) was the most frequent diagnosis. Five patients were treated with limb salvage surgery, and the remaining one had to undergo amputation. All patients received adjuvant treatment with chemotherapy. The 24-month survival rate was 100 %. Two patients presented a local recurrence before 24-months followup. Surgical treatment associated with chemotherapy seems to be the best therapeutic option. Local recurrence rate after limb salvage surgery is high for this group of patients.
