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Updated: Dec 25, 2025

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
Dendritic cell development in infection
Kristin Bieber1, Stella E Autenrieth1
1Department of Internal Medicine II, University of Tübingen, Germany.
Abstract:
The immune system protects from infections primarily by detecting and eliminating invading pathogens. This is predominantly mediated by innate immune cells like neutrophils, monocytes and dendritic cells (DCs) expressing specific receptors recognizing pathogen-associated molecular patterns. DC activation by pathogens leads to the initiation of antigen-specific adaptive immune responses, thereby bridging the innate and adaptive immune systems. However, various pathogens have evolved immune evasion strategies to ensure their survival. In this review, we highlight recent findings on how various microorganisms or their structural features affect or modulate DC development and whether this has any consequences for a protective immune response.
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