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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Scurvy: Forgotten diagnosis, but still exist.

Faisal Miraj1, Ali Abdullah2

  • 1Department of Orthopaedic - Traumatology, Fatmawati General Hospital, Indonesia.

International Journal of Surgery Case Reports
|March 22, 2020
PubMed
Summary

Scurvy, a rare vitamin C deficiency, can mimic other conditions like osteomyelitis in children. Prompt diagnosis and vitamin C treatment led to significant clinical and radiographic improvement in a pediatric case.

Keywords:
Clinical and radiological appearanceScurvyVitamin C administration

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Area of Science:

  • Pediatric Orthopedics
  • Nutritional Deficiencies
  • Radiology

Background:

  • Scurvy, a rare condition in children caused by vitamin C deficiency, often presents with musculoskeletal symptoms.
  • The rarity and varied clinical presentations of scurvy can lead to delayed or missed diagnoses, often mistaken for infections or tumors.

Observation:

  • A 3-year-old boy presented with a limping gait and lower limb swelling, initially diagnosed as osteomyelitis via MRI.
  • Despite antibiotic treatment and surgical debridement, the patient showed no improvement, with intraoperative findings of extensive blood clots and histopathology suggesting a fibro-osseous tumor.
  • Re-evaluation of clinical signs, including skin presentation and plain radiography, led to a suspicion of scurvy.

Findings:

  • Initiation of vitamin C therapy resulted in significant clinical and radiographic improvement within two weeks.
  • Serial radiographs at 2 and 12 months post-surgery demonstrated substantial healing of the affected area.

Implications:

  • This case highlights the importance of considering scurvy in pediatric patients with unexplained musculoskeletal symptoms, even when initial presentations suggest other diagnoses.
  • Clinical and radiological findings, particularly pathognomonic signs around joints, can be sufficient for diagnosing scurvy, especially when serum vitamin C levels are unavailable.
  • Early recognition and treatment of scurvy are crucial for favorable outcomes, preventing long-term complications.