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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
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Updated: Dec 25, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent fasting 5:2 diet: What is the macronutrient and micronutrient intake and composition?

E L Scholtens1, J D Krebs2, B T Corley2

  • 1Department of Medicine, University of Otago Wellington, Wellington, New Zealand.

Clinical Nutrition (Edinburgh, Scotland)
|March 23, 2020
PubMed
Summary

The 5:2 intermittent fasting diet (IF 5:2) results in a high-protein, low-carbohydrate intake, with decreased fiber and some micronutrient deficiencies. This dietary approach is a safe weight-loss strategy.

Keywords:
Intermittent energy restrictionIntermittent fastingObesityType 2 diabetesWeight loss

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Area of Science:

  • Nutritional Science
  • Dietary Interventions
  • Weight Management

Background:

  • Conventional weight-loss diets often lack long-term adherence.
  • Intermittent fasting (IF) is explored as an alternative, but its nutritional composition is under-researched.
  • The 5:2 IF diet involves two fasting days and five habitual intake days weekly.

Purpose of the Study:

  • To characterize the macronutrient and micronutrient intake of individuals following the 5:2 intermittent fasting diet (IF 5:2).

Main Methods:

  • Analysis of 4-day estimated food records from 38 overweight/obese participants (27 males, 11 females) with or without Type 2 Diabetes.
  • Dietary intake assessed at baseline and week six of the IF 5:2 intervention.
  • Records were weighted to determine mean daily intake during the intervention.

Main Results:

  • IF 5:2 resulted in a diet composition of 22% protein, 33% fat, and 39% carbohydrates.
  • Significant reductions in carbohydrate and fiber intake were observed from baseline to week six and on fasting days.
  • Intake of calcium, zinc, magnesium, and potassium was below recommended levels, while sodium intake exceeded targets. Protein intake increased on fasting days.

Conclusions:

  • The 5:2 IF diet is characterized by high protein, moderate fat, low carbohydrate, and low fiber intake.
  • Potential deficiencies in certain micronutrients warrant attention.
  • Overall, IF 5:2 is deemed a safe and acceptable strategy for weight loss.